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肥胖指数与心血管结果的关联变化:剂量反应元分析
Lyu Wang1, Hanyue Ding2, Yunyang Deng1
1The Jockey Club School of Public Health and Primary Care, Faculty of Medicine, the Chinese University of Hong Kong, Hong Kong SAR, China.
体重和BMI的变化会影响心血管疾病 (CVD) 的风险,腰围的增加与更高的死亡率有关. 建议根据年龄和健康状况进行量身定制的体重管理.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 心脏病学 心脏病学
背景情况:
- 肥胖指数的变化及其与心血管疾病 (CVD) 和死亡风险的关联尚未得到充分理解.
- 现有的研究缺乏对肥胖指数变化和健康结果之间的剂量反应关系的详细分析.
研究的目的:
- 对体重变化,体重指数 (BMI),腰围 (WC) 和其他肥胖指数与心血管疾病事件,心血管疾病特异性死亡和全因死亡率之间的关联进行剂量反应元分析.
主要方法:
- 对2023年1月8日之前发表的研究,在多个数据库 (MEDLINE,Embase,Web of Science,CINAHL,Scopus) 进行了全面的文献搜索.
- 用一阶段混合效应元分析来建模剂量-反应关系.
- 使用随机效应模型将相对风险 (RR) 和95%置信区间 (CI) 结合起来.
主要成果:
- 体重变化与心血管疾病和全因死亡率有负面关联,而增加的WC与更高的心血管疾病特异性死亡率有关.
- 观察到非线性关系,证实了增加WC对心血管疾病特异性死亡率的不良影响.
- 在体重/BMI变化和心血管疾病事件之间发现了显著的关联,根据年龄和先前存在的心血管疾病发生的变化. 体重/BMI的降低与老年人和心血管疾病患者的死亡率较高有关.
结论:
- 体重和BMI变化对心血管疾病结果的影响受年龄和心血管健康的影响.
- 建议包括量身定制的体重管理策略.
- 建议避免增加腰围,以减轻心血管疾病特异性死亡率.
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