败血症诱导的抑制淋巴结的收缩功能
M E Kosareva1, A V Chivildeev1, G I Lobov2
1I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia.
Bulletin of experimental biology and medicine
|February 9, 2024
概括
在老鼠中,结结和刺穿 (CLP) 后的炎症降低了淋巴结囊的收缩性. 像氧化和前列腺素这样的炎症调解剂可能会导致中腔淋巴结的收缩功能下降.
科学领域:
- 免疫学 免疫学 免疫学
- 身体生理学 身体生理学
- 血管生物学 血管生物学
背景情况:
- 炎症是许多疾病的关键组成部分.
- 淋巴系统在炎症过程中起着至关重要的作用,影响着炎症的开始和解决.
- 了解炎症期间的淋巴结功能对于理解全身反应至关重要.
研究的目的:
- 为了研究结和刺穿 (CLP) 诱导的炎症对大鼠中腔淋巴结的收缩功能的影响.
- 识别CLP后淋巴结收缩性的变化背后的分子机制.
主要方法:
- 在老鼠中使用结和刺穿 (CLP) 模型来诱导腹部炎症.
- 使用神经图片对中腔淋巴结收缩功能的ex vivo评估.
- 对关键炎症媒介体的表达分析,包括可诱导的氧化合成酶 (iNOS),环氧化原酶-2 (COX-2) 和氨酸-γ-酶 (CSE).
主要成果:
- 从CLP操作的老鼠的淋巴结表现出与假操作的对照相比显著降低了紧张.
- 在CLP大鼠的淋巴结中检测到iNOS,COX-2和CSE的表达增加.
- 发现炎症媒介氧化 (NO),前列腺素和硫化 (H2S) 抑制了淋巴结囊中的光滑肌细胞的收缩活性.
结论:
- 由CLP引起的炎症会损害老鼠中腔淋巴结的收缩功能.
- 观察到的收缩性下降归因于炎症媒介 (NO,前列腺素,H2S) 对淋巴结光滑肌细胞的抑制作用.
- 这些发现强调了一种新的机制,即炎症影响淋巴系统功能.
相关概念视频
01:23Detailed Structure and Function of Lymph Nodes
13.4K
Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
13.4K
01:15Development of the Lymphatic System
2.9K
The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
2.9K
01:25Acute Inflammation II: Local and Systemic Effects
82
Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...
82