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Updated: Jul 4, 2025

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells
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In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

Published on: September 28, 2017

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在生理和癌症相关的病理状况中,PI3K/AKT通路和昼夜钟之间的相互作用

Mohammad Rafi Khezri1, Hsiang-Yin Hsueh2, Somayeh Mohammadipanah1

  • 1Reproductive Health Research Center, Clinical Research Institute, Urmia University of Medical Sciences, Urmia, Iran.

Cell proliferation
|February 9, 2024
PubMed
概括

循环时钟的干扰通过与PI3K/AKT等细胞存活途径的交叉连接与癌症联系在一起. 了解这种相互作用是了解癌症进展的关键.

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Rapid Analysis of Circadian Phenotypes in Arabidopsis Protoplasts Transfected with a Luminescent Clock Reporter

Published on: September 17, 2016

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The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
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