基于神经成像的证据表明,在疼痛预期期间,大脑活动和外周血管运动之间存在交感相关性
Ziqiang Xu1, Zu Soh2, Yuta Kurota1
1Graduate School of Advanced Science and Engineering, Hiroshima University, 1-4-1 Kagamiyama, Higashi-Hiroshima, Hiroshima, 739-8527, Japan.
Scientific reports
|February 9, 2024
概括
预期疼痛涉及焦虑,但特定的动脉硬指数显示焦虑反应低,表明它.
科学领域:
- 神经科学是一个神经科学.
- 心理生理学 心理生理学
- 心血管生理学心血管生理学
背景情况:
- 预期疼痛,与焦虑和恐惧相关,影响疼痛感知和交感神经系统 (SNS) 的反应,包括外周血管运动.
- 在疼痛预测过程中,交感内置在血管度中的作用尚不清楚,尽管在疼痛感知过程中使用外围动脉硬度指数进行了量化.
研究的目的:
- 通过神经成像来调查外围动脉硬指数在不同程度的预期焦虑和疼痛感知期间的响应性和归因.
- 探索外围反应特异性的大脑基础以及外围和大脑对疼痛预期和感知的反应之间的时间相关性.
主要方法:
- 进行了一项功能磁共振成像 (fMRI) 实验,将视觉预测线索与两种强度的痛苦刺激相结合.
- 测量了外围动脉硬度指数,以及外围和脑血液动力学反应,以评估身体的反应和反应归因.
主要成果:
- 周围动脉硬度指数在疼痛感觉水平上显示出高响应性,但在预期焦虑水平上显示出低响应性,突显了其特异性.
- 在大脑活动中观察到疼痛感知和预期效应之间的差异,支持外围反应特异性的神经基础.
- 在疼痛预期和感知期间,在指数中注意到一个一致的1秒滞后,这表明了自上而下的交感神经系统内置.
结论:
- 交感神经系统以一种特定于情绪但又不受感觉偏见的方式对疼痛做出反应.
- 周围动脉硬度指数可能能够早期评估个人的疼痛感知.
- 整合外周和大脑血液动力学反应,可以全面了解身体对疼痛的反应.
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