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Updated: Jul 4, 2025

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修改瘤微环境可以通过等离子体基因疗法增强免疫力

Guilan Shi1, Jody Synowiec1, Julie Singh1

  • 1Department of Medical Engineering, University of South Florida, Tampa, FL, 33612, USA.

Cancer gene therapy
|February 10, 2024
PubMed
概括

质粒载体,而不仅仅是它们编码的分子,可以增强抗瘤免疫力. 在pUMVC3和pVax1载体的瘤内电穿孔上调MHC类I (MHC-I) 和PD-L1,减少小鼠模型中的瘤生长.

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
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