自身免疫性,自身炎症性疾病和皮肤恶性病与腺炎的关联:一个横截面研究
Hilliard T Brydges1, Ogechukwu C Onuh1, Rebecca Friedman1
1Hansjörg Wyss Department of Plastic Surgery, New York University Langone Health, 240 E 38th Street, 13th Floor, New York, NY, 10016, USA.
American journal of clinical dermatology
|February 10, 2024
概括
补腺炎 (HS) 与许多疾病有关,包括狼和多发性硬化症等自身免疫性疾病. 这项研究还在黑人HS患者中发现了新的皮肤癌联系.
科学领域:
- 皮肤病学和流行病学
- 自身免疫性和自身炎症性疾病
- 在瘤学瘤学.
背景情况:
- 补腺炎 (HS) 是一种严重的,痛苦的皮肤疾病,流行病学和病理生理学数据有限.
- 由于慢性炎症和形成,HS显著影响患者的生活质量.
研究的目的:
- 为了确定Hidradenitis Suppurativa (HS) 的流行率.
- 为了确定与HS的并发症关联.
- 探索HS与其他疾病之间的新相关性.
主要方法:
- 这是一项使用大型EPIC Cosmos数据库进行的横截面研究.
- 分析了超过1.8亿份美国患者病历.
- 计算流行率和几率比率 (OR),以确定并发症相关性.
主要成果:
- 在HS和代谢相关,心理和自身免疫/自身炎症 (AI) 疾病之间发现了显著的相关性.
- 最强烈的关联包括皮肤质,唐氏综合征和多囊性卵巢综合征.
- 在HS和狼,多发性硬化症 (MS),黑色素瘤和基底细胞癌 (BCC) 之间发现了新的关联,特别是在黑人患者中.
结论:
- 这项研究为黑人患者提供了HS和黑色素瘤/BCC之间的联系的第一个证据.
- 在所有患者群体中,HS与狼和多发性硬化症之间建立了新的相关性.
- 强调准确的诊断编码对于HS的流行病学研究的重要性.
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