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神经肌肉电刺激对多发性硬化症患者的脊柱刺激性没有影响

Martina Scalia¹, Riccardo Borzuola¹, Martina Parrella¹

¹Department of Movement, Human and Health Sciences, University of Rome "Foro Italico", 00135 Rome, Italy.

Journal of clinical medicine

|February 10, 2024

概括

神经肌肉电刺激 (NMES) 对多发性硬化症 (MS) 患者的影响与健康个体不同. 多发性硬化患者的H反射没有变化,这表明脊柱刺激度调节受损.

科学领域:

神经科学是一个神经科学.
康复医学康复医学康复医学
临床电生理学临床电生理学

背景情况:

神经肌肉电刺激 (NMES) 对多发性硬化症 (MS) 患者提供了功能上的好处.
在MS中NMES诱导的功能改善的潜在神经生理机制在很大程度上是未知的.
脊柱刺激性,通过索莱斯霍夫曼反射 (H-反射) 评估,是神经通路功能的关键指标.

研究的目的:

为了比较MS患者和健康对照者之间的急性脊柱刺激反应.
在被动NMES (pNMES),自愿收缩NMES (NMES+) 和自愿收缩 (ISO) 条件下研究H反射调制.
通过检查H反射变化,阐明MS中NMES的神经生理机制.

主要方法:

20名多发性硬化患者和20名健康对照人参加了一次实验.
参与者接受了三种条件:pNMES,NMES+和ISO,每个条件都涉及15次重复6秒的收缩,最大自愿同位数收缩率为20%.
在每个实验条件之前和之后测量H-反射幅度.

主要成果:

多发性硬化患者在所有三个条件 (ISO,pNMES,NMES+) 中都没有显示出H反射幅度的显著变化.
健康对照组在NMES+下显著增加H反射,在pNMES下显著减少.
在ISO条件下,健康对照组中H反射幅度保持不变.

结论:

多发性硬化患者和健康对照人群之间的独特的H反射反应表明,多发性硬化患者对调节脊柱刺激能力的能力受到损害.
这些发现突出了患有和没有MS的个体之间对NMES反应的潜在神经生理学差异.
需要进一步的研究,以了解脊柱刺激能力受损调节对MS康复中NMES疗效的影响.

关键词:

对于GABA来说,这是一个很好的选择.这是一种H反射.电刺激是一种电刺激.多发性硬化症多发性硬化症预突触抑制的抑制康复康复康复康复康复康复苏利乌斯 (Soleus) 是一个的植物.脊柱刺激性脊柱刺激性

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