自闭症谱系障碍中的头骨-面部特征:一个范围审查
Giuseppe Quatrosi1, Dario Genovese2, Giuseppe Galliano2
1Department of Psychology, Educational Science and Human Movement, University of Palermo, 90128 Palermo, Italy.
Journal of clinical medicine
|February 10, 2024
概括
面部特征,如增加的口腔间距离和面部中线高度降低,可能表明更严重的自闭症症状. 这些面异常可以作为早期自闭症谱系障碍 (ASD) 识别的潜在生物标志物.
科学领域:
- 神经发育障碍 神经发育障碍
- 遗传学和表观遗传学
- 生物标志物 生物标志物
背景情况:
- 自闭症谱系障碍 (ASD) 是一种复杂的神经发育状况,影响社会互动,沟通和行为.
- 面异常是神经发育障碍的已知的危险因素,促使人们对其与ASD的联系进行调查.
- 确定可靠的生物标志物对于早期ASD诊断和干预至关重要.
研究的目的:
- 进行对ASD患者头骨面部特征的最新科学文献进行范围审查.
- 探索面部形态学作为ASD诊断生物标志物的潜力.
- 调查特定面部表型与ASD症状严重程度之间的关联.
主要方法:
- 在PubMed/MEDLINE,Scopus和ERIC数据库中使用与ASD和面部形态学相关的特定关键词进行系统的文献搜索.
- 包括七项使用对面标志的定量分析的研究.
- 专注于该领域最近的研究进展.
主要成果:
- 面部异常,包括增加间距离和减少面部中线高度,与更大的ASD症状严重程度有关.
- 面部不对称和面部男子气概是更严重的ASD表现的潜在指标.
- 人类测量和仪器测量面部表型可以预测ASD症状严重程度.
结论:
- 面部异常的检查为及时识别ASD提供了潜在的可靠生物标志物.
- 特定的面表现型可以作为ASD症状严重程度的预测指标.
- 对面部形态的进一步研究可以提高ASD早期诊断和个性化治疗策略.
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