在斑点瘤解决后,分支视网膜静脉封闭中神经退行和视觉预后的变化
Chanjoon Park1, Ji Ho Lee2, Young Gun Park1,2
1Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.
Journal of clinical medicine
|February 10, 2024
概括
在分支视网膜静脉封闭 (BRVO) 眼睛的内视网膜稀释与已解决的斑点 (ME) 与视力敏度 (VA) 的降低有关. 质细胞层 (GCL) 厚度,而不是平均视网膜神经纤维层 (RNFL) 厚度,与视力结果相关.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 光学连贯性断层扫描技术
背景情况:
- 分支视网膜静脉封闭 (BRVO) 可能导致黄斑胀 (ME),可能导致视力丧失.
- 在ME解决后评估内视网膜层厚度对于了解BRVO患者的长期视觉预后至关重要.
研究的目的:
- 为了研究结节细胞层 (GCL) 和周状视网膜神经纤维层 (RNFL) 在 BRVO 眼睛的厚度,解决了 ME.
- 确定这些视网膜层厚度与最终视力敏度 (VA) 之间的关系.
主要方法:
- 追溯观察性病例控制研究,涉及57个BRVO眼睛与已解决的ME及其对侧未受影响的眼睛.
- 扫描源光学连贯性断层扫描 (SS-OCT) 用于测量斑点GCL厚度,周边斑点RNFL厚度和中央斑点厚度 (CMT).
主要成果:
- 虽然平均RNFL厚度没有显著差异,但在BRVO眼中,时间和鼻腔RNFL厚度显著减少.
- 受影响象限中的质细胞层 (GCL) 在BRVO眼睛中相比于不受影响的眼睛显著较薄 (p=0.02).
- 最终视力敏度 (VA) 与受影响区域的鼻腔和中部GCL厚度显著相关 (分别为r=-0.512,p=0.003和r=-0.537,p=0.001).
结论:
- 内视网膜损伤,特别是GCL稀释,即使在ME解决后,BRVO眼睛也会发生.
- 受影响眼睛特定区域的GCL厚度是BRVO患者视觉预后的重要预测指标.
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