在分娩期间的长期胆膜炎与后代的长期传染性发病之间的关联
Noa Efrat Davidi1, Gil Gutvirtz1,2, Eyal Sheiner1,2
1Faculty of Health Sciences, Joyce and Irving Goldman Medical School, Ben Gurion University of the Negev, Beer-Sheva 84105, Israel.
在分娩期间的长期胆膜炎不会增加孩子长期感染传染病的风险. 这项研究发现,儿童感染性发病率对于患有或不患有膜炎的母亲所产生的后代没有显著差异.
科学领域:
- 产科和妇科 产科和妇科
- 儿童传染病 儿童传染病
- 免疫学 免疫学 免疫学
背景情况:
- 在分娩期间的胆膜炎可能会改变胎儿的免疫发育,可能会增加对感染的易感性.
- 胚胎内感染对后代未来传染病风险的长期影响尚未完全理解.
研究的目的:
- 评估分娩期间的长期胆肌炎与长期儿科传染病发病率之间的关联.
- 为了确定是否暴露于子宫内膜炎会增加孩子对感染的易感性,直到18岁.
主要方法:
- 对单期分娩 (1991-2021) 的基于人口的队列分析.
- 对比18岁之前因传染性疾病住院的后代,在分娩期间有和没有母体胆炎.
- 使用卡普兰-梅尔曲线和考克斯回归来控制混因子的统计分析.
主要成果:
- 总共分析了331,598例分娩;其中988例 (0.3%) 涉及孕产妇的肌炎.
- 两组之间没有观察到传染病发病率的显著差异.
- 多变量分析证实,分娩期间的肌膜炎不是长期儿科传染病发病的危险因素 (HR 0.929,p=0.254).
结论:
- 在分娩期间的长期胆膜炎与儿童因感染住院的风险增加无关.
- 在分娩期间的胚胎内传染性/炎症状态似乎并没有增加术后后代对未来传染性发病的易感性.
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