患有COVID-19肺炎的重症患者的微量营养状况
Sander Rozemeijer1,2, Henrike M Hamer3, Annemieke C Heijboer4
1Department of Intensive Care Medicine, Research VUmc Intensive Care (REVIVE), Amsterdam Cardiovascular Science (ACS), Amsterdam Infection and Immunity Institute (AI&II), Amsterdam Medical Data Science (AMDS), Amsterdam UMC, Location VUmc, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.
危急的COVID-19患者在ICU入院时表现出高微量营养素缺乏. 额外的微量营养素IV治疗没有改善水平,表明再分配,而不是消费,可能会导致炎症期间的低水平.
科学领域:
- 关键护理医学 关键护理医学
- 营养科学 营养科学
- 传染病 传染病 传染病 传染病
背景情况:
- 微量营养素缺乏症在重症患者中很常见,原因是各种因素.
- 这些缺陷可能会损害免疫功能并影响患者的结果.
- 炎症可能导致微量营养素的再分配,模仿缺乏.
研究的目的:
- 在ICU住院的前三周内,研究重症COVID-19患者的血液微量营养素度.
- 评估额外的微量营养素给药对这些水平的影响.
- 探索炎症,疾病严重程度和微量营养素状况之间的关联.
主要方法:
- 在三周内对20名重症COVID-19患者进行试点研究.
- 每周测量维生素A,B6,D,E;铁;;铜;;CRP;以及SOFA分数.
- 接受标准护理的患者与接受额外静脉注射微量营养素的患者之间的比较.
- 使用线性混合模型和皮尔森相关性分析的数据.
主要成果:
- 维生素A,维生素B6,维生素D,和的初始缺乏率很高 (50-100%).
- 三周后,维生素B6,D的持续缺乏和低铁状态.
- 随着时间的推移,维生素A,E,和的血水平有所改善.
- 在接受标准微量营养素和额外微量营养素的组之间,微量营养素水平没有显著差异.
- 在炎症标志物 (CRP,SOFA评分) 和几个微量营养素 (维生素A,E,D,铁,,) 之间发现了负相关性.
结论:
- 危急的COVID-19患者在ICU入院时表现出高水平的微量营养素缺乏.
- 额外的静脉注射微量营养素并没有显著改善微量营养素水平.
- 观察到的低微量营养素水平可能部分是由于炎症驱动的再分配,而不是仅仅是消费.
- 解决与某些微量营养素水平自发增加相关的炎症.
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