特定于糖尿病的完整滑糖配方改善肥胖2型糖尿病患者的食后血糖反应:随机交叉试验
Pichanun Mongkolsucharitkul1, Bonggochpass Pinsawas1, Apinya Surawit1
1Siriraj Population Health and Nutrition Research Group, Department of Research Group and Research Network, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
一种新的滑奶配方 (SMMC) 改善了肥胖型2型糖尿病患者的葡萄糖控制和胰岛素敏感性,超过了标准配方. 这表明SMMC是糖尿病管理的有前途的功能性食品.
科学领域:
- 代谢研究的研究.
- 营养科学 营养科学
- 内分泌学 在内分泌学.
背景情况:
- 肥胖和2型糖尿病 (T2DM) 给我们的健康带来了重大挑战.
- 有效的营养管理对于T2DM的血糖控制至关重要.
- 标准的糖尿病特定营养配方 (DSNF) 已经存在,但正在探索新的配方.
研究的目的:
- 为了比较两种新的糖尿病特异性完整滑奶粉配方 (大豆制常规滑奶粉[SM]和改性碳水化合物滑奶粉[SMMC]) 与标准的DSNF (Glucerna) 的效果.
- 评估对肥胖T2DM患者葡萄糖稳定,胰岛素水平和脂质代谢的影响.
主要方法:
- 一项随机,双盲,交叉研究,涉及41名肥胖T2DM参与者.
- 参与者在不同的场合消耗了300千卡的SM,SMMC或Glucerna,并有7天的洗期.
- 饭后血糖,胰岛素,C-,葡萄糖和非化脂肪酸 (NEFA) 的反应通过曲线下的面积 (AUC) 从0-240分钟测量.
主要成果:
- 与Glucerna和SM (p <0.05) 相比,SMMC显著降低了葡萄糖AUC ((0-240)).
- 胰岛素和C-的AUC ((0-240)) 与SMMC相比显着较低,而不是Glucerna (分别p < 0.05和p < 0.001).
- 与SMMC相比,与SM和Glucerna相比,葡萄糖的AUC ((0-240)) 显著更高 (p <0.05),而NEFA抑制在SM中更大.
结论:
- 与Glucerna和SM相比,SMMC在肥胖T2DM患者中显示出更高的胰岛素敏感性.
- 通过改善胰岛素分泌或减少葡萄糖吸收,SMMC的独特成分可能会增强胰岛素敏感性.
- 这些发现表明,SMMC是一种潜在的有效功能性食品,可用于治疗糖尿病和肥胖症.
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