精密瘤学中的基因组酸代码:从饮食和代谢因素的机制性见解
Sultan Neja1, Wan Mohaiza Dashwood1, Roderick H Dashwood1,2
1Center for Epigenetics & Disease Prevention, Texas A&M Health, Houston, TX 77030, USA.
Nutrients
|February 10, 2024
概括
饮食习惯通过表观遗传变化影响癌症,特别是基因素酸化. 了解这个理解这个理解.
科学领域:
- 表观遗传学和癌症生物学
- 营养生物化学 营养生物化学
- 代谢调节 代谢调节 代谢调节
背景情况:
- 癌症的发展涉及复杂的遗传和非遗传因素,表观遗传学发挥着关键的调节作用.
- 糟糕的饮食会影响表观遗传机制,如DNA甲基化和基因质修饰,影响癌症倾向.
- 基因组转化后修饰 (PTMs),特别是化,将代谢状态转化为基因表达模式.
研究的目的:
- 审查饮食和新陈代谢衍生的基酸化在癌症进展中的作用.
- 探索超越乙化和它们对肠道微生物群的影响之外的特定的基因素化类型.
- 讨论用于癌症预防和治疗策略的基因组乙烯阅读器,写作器和擦拭器.
主要方法:
- 对癌症病因学中的表观遗传机制的文献综述.
- 分析饮食代谢物对基因组酸基因修饰的影响.
- 检查 histone 乙烯基修饰酶在癌症中的作用.
主要成果:
- 饮食习惯显著改变了组织酸酶的模式,影响了癌症的发展.
- 癌细胞中的新陈代谢重编程与特定的基因素化变化有关.
- 饮食中的代谢物可以重塑肠道微生物组,影响基因组酸氨基谱.
- 激素化动态与癌症进展有关,可以调节.
结论:
- "阿西尔代码"为癌症诊断和预后提供了新的见解.
- 向激素化途径为癌症预防和治疗提供了潜在的策略.
- 了解饮食,新陈代谢和表观遗传学之间的相互作用对于推进癌症研究至关重要.
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