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中度强度和高强度间歇运动训练在老鼠的2型糖尿病发展过程中提供了相同的心脏保护,具有不同的机制
Sarah D'Haese1,2, Lisa Claes1, Iris de Laat1
1UHasselt, Cardio & Organ Systems (COST), Biomedical Research Institute, Agoralaan, 3590 Diepenbeek, Belgium.
Nutrients
|February 10, 2024
概括
适度强度运动训练 (MIT) 和高强度间歇训练 (HIIT) 都可以预防2型糖尿病 (T2DM) 的心脏问题. 这些运动类型可能使用不同的适应机制来保护心脏.
科学领域:
- 心血管生理学心血管生理学
- 运动科学 运动科学
- 代谢性疾病研究研究
背景情况:
- 2型糖尿病 (T2DM) 与不良的心脏重塑和功能障碍有关.
- 对于T2DM中心脏保护的最佳耐力运动强度尚不清楚.
- 在老鼠中食用西方饮食 (WD) 可以诱导T2DM和心脏病理.
研究的目的:
- 研究同热量中等强度运动训练 (MIT) 和高强度间歇运动训练 (HIIT) 对T2DM大鼠模型中的心脏重塑和功能障碍的影响.
- 探索麻省理工学院和HIIT发挥心脏保护作用的潜在分子机制.
主要方法:
- 雄性大鼠被食WD来诱导T2DM,然后被分配到久坐,MIT或HIIT组.
- 用心声图和侵入性血液动力学来评估心脏功能.
- 分析了基因表达 (qPCR) 和左心室 (LV) 组织组织组织学,以了解细胞机制.
主要成果:
- 与久坐的老鼠相比,MIT和HIIT都阻止了T2DM的发展,并预防了病态的LV缩和腹功能障碍.
- HIIT提高了与氧化压力相关的基因 (NOX4) 和抗氧化防御 (SOD2,glyoxalase 1) 的调节.
- 这两种干预都增加了促炎性标记物,而麻省理工学院也促进了抗炎性巨细胞标记物.
结论:
- 麻省理工学院和HIIT都有效预防与T2DM相关的心脏并发症,这些并发症是由老鼠的WD引起的.
- 麻省理工学院和HIIT似乎采用了不同的适应机制,涉及对炎症和氧化应激途径的差异调节.
- 需要进一步的研究来阐明这些途径在运动中介心脏保护中的特定作用.
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