维特克斯属作为抗菌剂的来源
Zohorul Islam1, Gonçalo I Caldeira1, Manuela Caniça2
1Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, University of Lisbon, 1649-003 Lisbon, Portugal.
Plants (Basel, Switzerland)
|February 10, 2024
概括
维泰克斯植物对各种细菌和真菌表现出显著的抗菌活性. 这些药用植物是开发新的天然抗菌剂的有希望的来源,需要进一步研究.
科学领域:
- 民族植物学 民族植物学
- 药理学 药理学是指药理学的学科.
- 自然产品 化学 化学
背景情况:
- 兰科 (Lamiaceae) 家族中最大的属,Vitex,在传统医学中被广泛使用.
- 传统上,Vitex物种用于可能与传染病相关的疾病.
研究的目的:
- 系统地审查Vitex植物作为抗菌剂来源的潜力.
- 巩固关于Vitex物种及其衍生化合物的抗菌性质的证据.
主要方法:
- 按照PRISMA方法进行系统审查.
- 选了2610个出版物,选择了141个相关的文章用于数据分析.
主要成果:
- 维泰克斯物种在体外表现出对关键病原体的抗微生物活性,包括大肠杆菌和金黄色葡萄球菌.
- 维泰克斯 (Vitex agnus-castus) 和维泰克斯 (Vitex negundo) 被广泛研究,显示它们对细菌,真菌 (Aspergillus niger,Candida albicans),病毒 (HIV-1) 和寄生虫 (Plasmodium falciparum) 的活性.
- 像negundoside这样的已识别的化合物表现出强大的抗菌作用,特别是针对金黄色葡萄球菌 (MIC 12.5μg/mL).
结论:
- 维泰克斯物种是新型天然抗菌剂的宝贵资源.
- 需要进行进一步的实验研究,以充分阐明Vitex衍生抗菌素的治疗潜力.
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