芬兰乳牛患有数字皮肤炎的局部和全身炎症
Hertta Pirkkalainen1, Aino Riihimäki1, Taru Lienemann2
1Department of Production Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Paroninkuja 20, 04920 Saarentaus, Finland.
Animals : an open access journal from MDPI
|February 10, 2024
概括
乳牛的数字皮肤炎会激活促炎细胞因子,特别是白蛋白-1β,但不能激活急性阶段蛋白质. 开发了一种新的组织病理学分级系统,以评估病变的严重程度和螺旋体的存在.
科学领域:
- 兽医皮肤病学 兽医皮肤病学
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
背景情况:
- 数字性皮肤炎是乳牛腿和福利问题的重要原因.
- 了解炎症反应对于管理这种疾病至关重要.
研究的目的:
- 评估数字皮肤炎的乳牛的局部和全身炎症反应.
- 将宏观和组织学发现与炎症标志物进行比较.
- 为数字性皮肤炎病变开发一种全新的组织病理学分级系统.
主要方法:
- 对104只奶牛脚进行了宏观评估.
- 皮肤活检的组织学检查.
- 血清分析急性阶段蛋白质 (血清粉样蛋白A,哈普托格洛宾) 和促炎性细胞因子 (交白素-1β,交白素-6,瘤缩因子-α).
主要成果:
- 与健康奶牛相比,患有活跃和非活跃数字皮肤炎病变的奶牛的血清中白蛋白-1β水平较高.
- 带有亡的病变具有显著更高的互白素-1β度.
- 在健康和受影响的奶牛之间,在其他细胞因子或急性阶段蛋白质度上没有发现显著差异.
- 开发了一种新型的组织病理学分级系统,将病变严重程度,亡,和螺旋体的存在联系起来.
结论:
- 数字性皮肤炎会激活促炎性细胞因子,尤其是白细胞介素-1β.
- 炎症反应似乎没有触发全身急性阶段蛋白质释放.
- 开发的组织病理学分级系统有助于理解疾病的进展,螺旋虫可能是死角性病变中的二次入侵者.
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