猪辅助性腺的发展 猪辅助性腺的发展
Trish Berger1, Valerie Guerrero1, Rosalina Boeldt1
1Department of Animal Science, University of California, Davis, CA 95616, USA.
Animals : an open access journal from MDPI
|February 10, 2024
概括
在新生猪中抑制雌激素的产生刺激了辅助性腺的生长,主要影响精液囊和前列腺. 这种效应是暂时的,腺体体重在发育后期正常化.
科学领域:
- 生殖生物学 生殖生物学
- 内分泌学 在内分泌学.
- 发育生物学是发展生物学.
背景情况:
- 辅助性腺对于牲畜的繁殖成功至关重要.
- 内生类固醇显著影响这些腺体的发育,特别是在新生儿时期.
研究的目的:
- 调查内源性雌激素对猪辅助性腺发育的影响.
- 阐明参与调解这种效应的特定雌激素受体通路.
主要方法:
- 新生猪被用莱特治疗,以抑制雌激素的产生.
- 在不同年龄段 (6.5周,20周和40周) 测量了辅助性腺体重.
- 使用富尔韦斯特兰特 (雌激素受体) 和胺 (雄激素受体) 进行受体阻塞实验.
主要成果:
- 通过莱特醇抑制雌激素合成,在 6.5 周大时显著增加了辅助性腺体重 (精液囊,前列腺,腹膜腺).
- 这种生长刺激是短暂的,腺体体重在20周和40周正常化.
- 内源性雌激素似乎通过G蛋白结合雌激素受体抑制辅助性腺发育,而不是经典的核雌激素受体或雄激素受体.
结论:
- 内源性雌激素在猪辅助性腺的新生儿发育中起抑制作用.
- 与G蛋白结合的雌激素受体是新生儿到早期青春期期间这种雌激素抑制的主要媒介.
- 这些发现对了解牲畜的生殖健康和疾病有影响.
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