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牛甲流感-3病毒检测方法和牛中的流行:系统性审查和元分析
Gebremeskel Mamu Werid1, Thien D Van1, Darren Miller1
1Davies Livestock Research Centre, School of Animal & Veterinary Sciences, University of Adelaide, Roseworthy Campus, Roseworthy, SA 5371, Australia.
Animals : an open access journal from MDPI
|February 10, 2024
概括
牛甲型流感-3病毒 (BPI3V) 显著影响牛的呼吸系统健康. 它的全球流行程度因检测方法而异,这凸显了对这一关键的BRDC病原体进行专注研究的需要.
科学领域:
- 兽医病毒学 兽医病毒学
- 流行病学 流行病学
- 动物健康 动物健康
背景情况:
- 牛甲型流感-3病毒 (BPI3V) 是牛的重要呼吸道病原体.
- 它有助于牛呼吸道疾病综合体 (BRDC),影响牛群健康和生产力.
- 目前对BPI3V患病率的理解,特别是在BRDC的背景下,是分散的.
研究的目的:
- 系统地审查和元分析全球牛群BPI3V的流行情况.
- 调查不同检测方法如何影响观察到的BPI3V流行率.
- 为了确定与牛中BPI3V感染相关的潜在风险因素.
主要方法:
- 系统的文献搜索和对来自32个国家的71项选定的研究进行元分析.
- 基于各种检测方法 (抗体,抗原,核酸,病毒隔离) 的BPI3V流行数据的分析.
- 探索潜在的影响因素,包括共感染,农场规模和临床症状.
主要成果:
- 全球BPI3V患病率因检测方法而有显著差异.
- 抗体检测显示出患病率最高 (一般人群0.64,BRDC病例0.75).
- 核酸和病毒隔离方法报告了较低的流行率 (分别为0.05-0.10和0.04-0.05).
结论:
- 检测方法对牛中BPI3V报告的流行率产生了重大影响.
- BPI3V是BRDC的重要贡献者,但其具体作用可能被低估.
- 对BPI3V进行进一步的专门研究对于有针对性的疾病控制策略至关重要.
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