聚合物纳米颗粒含有2-HP-β-Cyclodextrin,用于增强 HCE-T 细胞中吸收的保留
Zhenmiao Qin1, Baohua Li2, Qiyi Deng2
1Hainan Key Laboratory for Research and Development of Tropical Herbs, School of Pharmacy, Hainan Medical University, Haikou 571199, China.
Molecules (Basel, Switzerland)
|February 10, 2024
概括
新型PLGA纳米颗粒具有水性涂层,可增强三氨乙化物 (TA) 的眼部药物输送. 这种非侵入性方法可以改善角膜的透性和生物可用性,用于治疗后眼部疾病.
科学领域:
- 眼部药物输送 眼部药物输送
- 纳米技术纳米技术
- 药品制造 药品制造 药品制造
背景情况:
- 氨酸 (TA) 是一种葡萄糖皮质类药物,用于通过玻璃体注射治疗眼睛后部疾病.
- 目前的输送方法面临着眼障碍的挑战,限制了局部药物的有效性.
研究的目的:
- 设计和描述使用PLGA载体用于局部TA输送的新型眼睛纳米配方.
- 为了克服眼睛的障碍,并提高药物透到眼睛组织.
主要方法:
- 使用乳化溶剂挥发的水性PLGA纳米颗粒 (NP) 开发,其中包括2-基-β-环氧 (2-HP-β-CD).
- 利用罗达胺B (Rh-B) 光探针研究角膜上皮细胞中纳米颗粒的吸收.
- 评估了体外释放,角膜透性和水性幽默中的体内药理动力学.
主要成果:
- 在200 nm范围内特征化TA载荷NP (TA-(2-HP-β-CD) /PLGANP) 和Rh-B探针,显示均性和稳定性.
- 通过上皮屏障证明了NP的时间依赖,活跃的运输.
- 药物释放时间延长 (比悬浮剂长3倍),角膜透率提高 (增加7.99倍),水性幽默生物利用率显著提高 (51.91倍以上的Cmax).
结论:
- 水友性PLGA纳米颗粒通过改善跨膜吸收和角膜透性,有效地增强眼部药物输送.
- 开发的纳米配方显著提高了药物在水性幽默中的生物可用性.
- 这项研究支持非侵入性纳米配方的潜力,用于跨眼障碍药物输送.
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