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基于氨酸的共生菌作为一种针对非酒精性脂肪性肝病 (NAFLD) 的新策略 降低风险
Wasitha P D W Thilakarathna1, H P Vasantha Rupasinghe1,2
1Department of Plant, Food, and Environmental Sciences, Faculty of Agriculture, Dalhousie University, Truro, NS B2N 5E3, Canada.
Molecules (Basel, Switzerland)
|February 10, 2024
概括
协生菌中的益生菌与益生菌相结合的益生菌素 (PAC) 显示出对抗非酒精性脂肪性肝病 (NAFLD) 的希望. 这种方法提高了PAC的生物可用性,为应对这种日益严重的全球健康问题提供了一种新的策略.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 营养科学 营养科学
- 微生物学 微生物学
背景情况:
- 非酒精性脂肪肝 (NAFLD) 是一种普遍存在的全球性肝脏疾病,其特点是过度的脂质积累,发病率迅速增加.
- 黄类药物,特别是益阳西氨素 (PACs),显示出降低NAFLD风险的潜力,但由于其生物可用性较低,其有效性受到限制.
- 通过将PAC与益生菌结合起来,开发共生菌可以通过生物转化为可生物利用的代谢物来提高它们的有效性.
研究的目的:
- 探索基于PAC的协生菌的潜力,作为减轻NAFLD日益增长的全球负担的新战略.
- 研究PAC和益生菌单独或组合影响NAFLD进展的机制.
主要方法:
- 该研究的重点是益生菌配方中的益生菌和益生菌对益生菌素 (PAC) 的协同效应.
- 机理性见解包括评估抑制de novo脂质生成和促进脂肪酸β-氧化.
- 评估肝损伤和炎症的改善,解决肝氧化应激,内分泌网膜应激和肠道微生物群失调.
主要成果:
- 环保药物和益生菌通过抑制新型脂质生成和增强脂肪酸β-氧化,有效地减轻脂肪酸症.
- 与单个成分相比,组合的PAC-益生菌协生菌在降低NAFLD风险方面表现出更高的有效性.
- 协生菌有效地通过减轻肝脏损伤和炎症来减少从肥胖症到非酒精性肥胖肝炎 (NASH) 的进展.
结论:
- 基于PAC的协生菌是一种有前途的新战略,可以缓解NAFLD发病率的上升.
- 将PAC与益生菌结合在一起,可以提高对NAFLD的有效性,因为生物可用性和协同机制得到了改善.
- 这种方法具有管理和减少全球NAFLD负担的潜力.
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