多孔曼尼托尔的制造,药物加载和释放行为
Zhe Li1, Xiaosui Luo1, Qiong Li1
1Key Laboratory of Modern Preparation of TCM of Ministry of Education, Institute for Advanced Study, Jiangxi University of Chinese Medicine, Nanchang 330004, China.
Molecules (Basel, Switzerland)
|February 10, 2024
概括
通过与PVP K30一起使用共喷雾抗溶剂方法制造的多孔曼尼托尔,有效地提高了水溶性较差的药物如黄素和布洛芬的溶性. 这种新型药物载体显示出改善药物输送系统的巨大潜力.
科学领域:
- 材料科学 材料科学 材料科学
- 制药技术 制药技术 制药技术
- 药物运输 药物运输 药物运输
背景情况:
- 多孔材料对于提高水溶性较差的药物的可溶性和生物利用性至关重要.
- 曼尼托是制药配方中广泛使用的辅助剂.
- 开发有效的多孔载体对于提高药物疗效至关重要.
研究的目的:
- 为了研究多孔曼尼托尔作为一种药物载体,用于水溶性较差的药物.
- 探索多孔曼尼托的制造,药物加载和释放机制.
- 通过调整模板剂度来优化孔隙结构.
主要方法:
- 使用共喷雾抗溶剂工艺制造多孔曼尼托尔,使用聚烯利 K30 (PVP K30) 作为模板剂.
- 系统地描述多孔曼尼托尔的形态和特性.
- 将黄素和易布洛芬加载到多孔曼尼托尔中,并分析它们的释放概况.
主要成果:
- 通过调整PVP K30模板剂量,可以成功制造出多孔曼尼托尔,可通过调整PVP K30模板剂量来控制多孔大小.
- 随着模板度的变化 (1%,3%,5%),观察到曼尼托尔孔径的显著增加.
- 根据Korsmeyer-Peppas模型,黄素和布洛芬的加载导致分别达到69%和70%的累积溶解.
结论:
- 联合喷雾抗溶剂方法对于快速制造多孔材料是有效的.
- 多孔曼尼托尔显示出大量的潜力,可以溶解水溶性较差的药物.
- 这项研究为开发先进的多孔药物递送系统提供了宝贵的见解.
相关概念视频
01:28Factors Influencing Drug Absorption: Pharmaceutical Parameters
134
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
134
01:17Pore Transport and Ion-Pair Transport
452
Pore transport and ion-pair formation are critical mechanisms for the absorption and distribution of drugs in the body.
Pore transport, also known as convective transport, is a process where small molecules like urea, water, and sugars rapidly cross cell membranes as though there were channels or pores in the membrane. Although direct microscopic evidence is limited but the concept of pores or channels is widely accepted based on physiological evidence. Despite the lack of direct...
Pore transport, also known as convective transport, is a process where small molecules like urea, water, and sugars rapidly cross cell membranes as though there were channels or pores in the membrane. Although direct microscopic evidence is limited but the concept of pores or channels is widely accepted based on physiological evidence. Despite the lack of direct...
452
01:21Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism
308
Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
308