Rosc对抗生素相关的腹和改善肠道功能的改善作用
Sung Jin Kim1, Myoung-Sook Shin1, You-Kyung Choi1
1College of Korean Medicine, Gachon University, Seongnam 13120, Republic of Korea.
紫杉官 (ZO) 提取物通过恢复肠道屏障功能和使短链脂肪酸 (SCFA) 正常化,改善了小鼠的抗生素相关腹 (AAD). 这种天然疗法可以加强肠道健康,并对抗AAD的副作用.
科学领域:
- 药理学 药理学是指药理学的学科.
- 胃肠病学 胃肠病学
- 自然产品 化学 化学
背景情况:
- 增加抗生素消费与抗生素相关的腹 (AAD) 等不良影响相关.
- 维持肠道平衡对于肠道健康至关重要,涉及关键蛋白质,如溶酶,Claudin-1和α-defensin-1.
- 短链脂肪酸 (SCFA) 在肠道健康中起着至关重要的作用.
研究的目的:
- 为了研究Zingiber officinale (ZO) 提取物的化学特性.
- 在小鼠模型中评估ZO提取物对林氏素诱导的AAD的改善作用.
- 评估ZO提取物对肠道平衡标志物和SCFA水平的影响.
主要方法:
- 对中性糖,酸性糖,蛋白质,多和单糖组成 (葡萄糖,银糖) 的ZO提取物进行化学分析.
- 在小鼠中使用lincomycin诱导AD.
- 将ZO提取物给ADD诱导的小鼠.
- 评估肠道组织对lyszyme,claudin-1和α-defensin-1的表达.
- 对内SCFA度的分析.
主要成果:
- 对ZO提取物的化学分析显示,中性糖含量高 (86.4%),葡萄糖是主要单糖 (97.3%).
- 施用ZO提取物改善了AAD症状,包括体重减轻和异常摄入水分.
- 用ZO提取物的治疗使lyszyme,α-defensin-1和claudin-1的表达正常化.
- ZO提取物恢复了AAD诱导小鼠的盲体中的SCFA水平降低.
结论:
- 树官网提取物在改善抗生素相关的腹方面表现出显著的有效性.
- ZO提取物通过恢复关键蛋白质表达来加强肠道屏障.
- ZO提取物使肠道微生物群的代谢物正常化,由SCFA水平的恢复证明,这表明强大的肠道功能强化作用.
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