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对Akkermansia muciniphila的表征和初步安全评估 PROBIO

Xin Ma¹, Meng Tian², Xueping Yu¹

¹State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China.

Foods (Basel, Switzerland)

|February 10, 2024

概括

这项研究证实了Akkermansia muciniphila PROBIO作为益生菌的安全性. 严格的测试没有显示任何不良影响,支持其在食品应用中的使用.

科学领域:

微生物学微生物学
毒理学毒理学毒理学
益生菌研究的研究.

背景情况:

益生菌需要一个明确的安全性,以及健康益处.
一种新型细菌菌株,Akkermansia muciniphila PROBIO,从人类便中分离出来.

研究的目的:

对Akkermansia muciniphila PROBIO进行全面的安全评估.
评估其基因毒性,药物敏感性和毒理影响.
确定其适用于食品应用的适用性.

主要方法:

评估了胃肠道耐受性,生理和生化特征.
进行了细菌逆变异和体外哺乳动物细胞微核测试.
分析了抗生素耐药性基因,进行了急性和亚慢性毒性研究,并进行了基因组安全评估.
通过体外结合来研究莫西素耐药性的转移.

主要成果:

证明了优越的胃肠道耐受性,没有血液学或组织病理学异常.
已证实,即使在高剂量下,对原体,克拉斯托基因和毒性影响的负面结果.
确定了6.4 × 10^11个可活细菌的无观察不良影响水平 (NOAEL).
鉴定了有限的潜在耐药性和毒性基因;莫西素耐药性是内在的,不可转移的.

结论:

阿克尔曼西亚·穆西尼菲拉 (Akkermansia muciniphila PROBIO) 具有强大的安全性.
这种菌株适合纳入食品.
综合的安全数据支持其作为益生菌的使用.

关键词:

阿克尔曼西亚木类动物生活.抗生素抗生素是一种抗生素.基因组基因组是基因组的组成部分.在安全方面,安全是安全的.毒性的毒性毒性的毒性

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