结合GTP的N-Ras符合状态和子状态是通过膜和点突变调节的

Alexandra Farcas1, Lorant Janosi1

  • 1Department of Molecular and Biomolecular Physics, National Institute for Research and Development of Isotopic and Molecular Technologies, 67-103 Donat Street, 400293 Cluj-Napoca, Romania.

概括

瘤性N-Ras蛋白显示出一种新的构造基质,影响癌症的发展. 这一发现揭示了突变如何破坏正常的Ras蛋白功能,并突出了膜在Ras信号传递中的作用.

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