TonEBP:在脑内出血引发的神经炎症后,微质中的一个关键转录因子

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Ailiyaer Palahati^1,2, Yujia Luo^1,2, Le Qin^1,2

¹Department of Neurosurgery Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Chongqing 400010, China.

International journal of molecular sciences

|February 10, 2024

概括

在脑出血后,微质中的性响应增强剂结合蛋白 (TonEBP) 增加. 通过调节Pellino-1 (PELI1) 表达,TonEBP促进炎症和NF-κB信号传递.

科学领域:

神经科学是一个神经科学.
免疫学免疫学免疫学
分子生物学分子生物学

背景情况:

微质细胞在脑内出血 (ICH) 后的神经炎症中起着关键作用.
微质中的转录因子调节炎症反应,但微质TonEBP在ICH中的作用尚不清楚.

研究的目的:

研究微质度响应增强剂结合蛋白 (TonEBP) 在脑内出血 (ICH) 诱导的神经炎症中的作用.
确定参与调节炎症信号通路的TonEBP下游目标.

主要方法:

生物信息学查以确定TonEBP.
在人类和小鼠ICH脑组织中对TonEBP表达的分析.
TonEBP在微质中进行了用脂多糖 (LPS) 刺激的敲除实验.
对TonEBP缺乏细胞的转录组测序.
切割和运行,双化酶记者测定,和qPCR验证TonEBP与Peli1促进体结合.

主要成果:

ICH增加了TonEBP在周围血瘤组织中的微质中的表达.
在TonEBP中降低了LPS诱导的炎症和微质中的NF-κB信号激活.
证实TonEBP是Pellino-1 (PELI1) 的转录因子,与其促进体结合.
PELI1是TonEBP的下游目标,参与NF-κB信号传输.

结论:

在ICH之后,TonEBP在微质上升调节,并导致神经炎症.
TonEBP促进LPS诱导的炎症和NF-κB激活,可能通过其调节PELI1.
在ICH后,TonEBP代表了缓解神经炎症的潜在治疗标.

关键词:

这就是NF-κBB.在PELI1的基础上,PELI1 在TonEBP中使用.这是一种炎症炎症炎症炎症.脑内出血脑内出血

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