不利的童年经历和多发性硬化发展的风险:对潜在机制的审查
Karine Eid1,2, Marte-Helene Bjørk1,2,3, Nils Erik Gilhus1,2
1Department of Neurology, Haukeland University Hospital, Jonas Lies vei 71, 5053 Bergen, Norway.
International journal of molecular sciences
|February 10, 2024
概括
童年不良经历 (ACE) 与增加多发性硬化症 (MS) 风险有关. ACEs可以破坏神经发育和免疫功能,通过表观遗传变化和爱斯坦-巴尔病毒重新激活等机制,可能有助于MS发展.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 儿童不良经历 (ACE) 导致有毒压力和炎症.
- ACE 与增加对多发性硬化症 (MS) 和实验性自身免疫脑膜炎的敏感性有关.
- 早期的压力会影响神经发育,应激反应和免疫反应.
研究的目的:
- 审查证据,将ACE与增加的MS风险联系起来.
- 探索可能调解ACEs-MS关联的生物机制.
- 讨论表观遗传变化和爱斯坦-巴尔病毒 (EBV) 活性化作为潜在的途径.
主要方法:
- 对观察性研究和动物模型的文献综述.
- 对潜在的神经发育和免疫路径的分析.
- 讨论表观遗传修饰和病毒再激活.
主要成果:
- ACEs与失调的神经发育,压力反应和免疫反应相关.
- ACEs可能会改变与MS风险相关的免疫系统-神经网络相互作用.
- ACEs可以诱导表观遗传变化,并可能重新激活EBV,这是已知的MS风险因素.
结论:
- ACEs代表了MS发展的重要风险因素.
- 了解ACE对免疫和神经系统的影响对于预防MS至关重要.
- 需要进一步的研究来阐明精确的机制,并制定有针对性的干预措施.
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