孕妇表观遗传甲基化变化:双暴露和亚托皮肤炎
Seung Hwan Kim1, So Yeon Yu2, Jeong Hyeop Choo2
1Department of Bio-Nanotechnology, Hanyang University, Ansan 15588, Republic of Korea.
International journal of molecular sciences
|February 10, 2024
概括
怀孕期间暴露于BPA,BPS和BPF等双醇可能会影响亚托皮炎 (AD) 风险. 这些化学物质改变了对孕妇免疫功能和皮肤屏障健康至关重要的基因的DNA甲基化.
科学领域:
- 环境表观遗传学环境表观遗传学
- 皮肤病学 皮肤病学
- 毒理学 毒理学 毒理学
背景情况:
- 双,包括双A (BPA) 和其替代品双S (BPS) 和双F (BPF),在消费品中普遍存在.
- 基因甲基化是基因表达的关键表观遗传调节剂,易受环境影响.
- 表观遗传变化与免疫媒介疾病的发展和进展有关,如阿托皮性皮肤炎 (AD).
研究的目的:
- 调查产前暴露于BPA,BPS和BPF与DNA甲基化模式之间的联系.
- 探索潜在的表观遗传机制,将双暴露与孕妇的亚托皮炎 (AD) 联系起来.
主要方法:
- 从孕妇的外围血液单核细胞 (PBMCs) 中分析DNA甲基化.
- 对BPA,BPS和BPF暴露水平的评估.
- 在JAK-STAT和PI3K-AKT信号通路中检查基因甲基化状态.
主要成果:
- 在暴露于双的孕妇中,在JAK-STAT和PI3K-AKT信号通路的基因中观察到显著的低甲基化.
- 这些通路对于保持皮肤屏障完整性和调节免疫反应至关重要.
- 这些途径的改变甲基化表明,与阿托皮性皮肤炎 (AD) 有潜在的表观遗传联系.
结论:
- 产前暴露于BPA,BPS和BPF可能会通过表观遗传修饰对亚托皮炎 (AD) 风险产生负面影响.
- 双替代品 (BPS,BPF) 可能会通过表观遗传破坏对公众健康构成类似的风险,比如BPA.
- 需要进一步的研究来阐明双诱导的表观遗传变化在AD病变发生过程中的确切作用.
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