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Updated: Jul 3, 2025

Author Spotlight: Deciphering the Role of ATM in Ataxia-Telangiectasia and the Associated Cerebellar Degeneration
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Published on: December 27, 2024

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该ATM Ser49Cys变体影响ATM功能,作为瘤基因诱导衰老的调节剂

Caroline Atkinson1, Aideen M McInerney-Leo2, Martina Proctor1

  • 1Mater Research Institute, The University of Queensland, Brisbane, QLD 4102, Australia.

International journal of molecular sciences
|February 10, 2024
PubMed
概括

突变的阿塔克西亚-泰朗吉克塔西亚 (ATM) Ser49Cys变体显示正常的急性DNA损伤反应,但在慢性瘤基因压力下功能减弱,可能会改变其他遗传风险.

关键词:
这是一个ATMATMATM.造成的DNA损伤是DNA损伤.电离辐射辐射的电离辐射.在 p53 里,p53 是一个 p53 的类型.衰老是一种老化.

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