安努尔卡果油脂为配制具有皮肤衰老活性的化品的功能成分
Ritamaria Di Lorenzo1, Maria Maisto2, Lucia Ricci1
1RD Cosmetics, Department of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy.
International journal of molecular sciences
|February 10, 2024
概括
富含乌尔索酸的Annurca果油脂酸有效减少纹,改善皮肤弹性. 这种天然疗法显示出对抗老化皮肤管理的显著化品潜力.
科学领域:
- 皮肤病学和化学
- 自然产品化学 自然产品化学
- 生物化学 生物化学
背景情况:
- 皮肤老化管理是一个日益关注的问题,推动寻找有效的自然疗法.
- 在Annurca果 (AA) 果实中丰富的乌尔索酸 (UA) 显示出有前途的化品特性.
- 含有UA的提取物AA油脂 (AAO) 值得对其抗衰老潜力进行调查.
研究的目的:
- 评估AAO抑制猪弹性酶酶活性的能力.
- 评估局部AAO配方的抗和皮肤粘性效应.
- 调查AAO对皮肤水分参数的影响.
主要方法:
- 谱光测定测试以确定AAO,UA和Quercetin的弹性酶抑制 (IC50值).
- 一项为期28天的,安慰剂控制的,双盲临床研究,涉及40名志愿者,使用2.5%的AAO局部配方.
- 评估纹深度 (鼻皮,额头),皮肤粘性弹性 (R0,R2) 和水分 (TEWL,皮肤导电).
主要成果:
- AAO显示出显著的弹性酶抑制 (IC50: 212.76 mg/mL),与纯UA (IC50: 135.24 μg/mL) 相比.
- 在28天后,局部AAO显著降低了鼻唇深度 (-7.2) 和额头纹 (-5.3).
- 观察到皮肤柔性/坚固度 (R0: -13%) 和弹性 (R2: +12%) 的显著改善.
结论:
- 安努尔卡果油脂具有显著的弹性酶抑制活性,这表明它具有抗衰老的好处.
- 局部应用AAO配方有效减少纹,增强皮肤粘性弹性.
- AAO显示出作为化品抗衰老产品的天然成分的潜力.
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