尿路微生物组在健康和疾病中的作用:与膀癌的相关性
Natasa Kustrimovic1, Giorgia Bilato2, Lorenzo Mortara2
1Center for Translational Research on Autoimmune and Allergic Disease-CAAD, Università del Piemonte Orientale, 28100 Novara, Italy.
International journal of molecular sciences
|February 10, 2024
概括
尿路微生物组分析揭示了健康人与膀癌 (BC) 患者之间的差异. 需要进一步的研究来证实尿路微生物组在BC发育和治疗反应中的因果作用.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 微生物学 微生物学
- 在瘤学瘤学.
背景情况:
- 膀癌 (BC) 是一种全球普遍存在的恶性瘤.
- 在BC患者中,与健康个体相比,观察到尿路微生物组的改变.
- 微生物群失调和BC病原体之间的直接因果关系需要进一步阐明.
研究的目的:
- 在健康和疾病中审查尿路微生物群.
- 讨论BC.微生物组参与的证据和机制.
- 探索尿路微生物群对BC风险分层和治疗预测的分析.
主要方法:
- 关于尿路微生物群的研究的文献综述.
- 分析高通量测序数据的分析.
- 在BC中讨论宿主-微生物相互作用.
主要成果:
- 在BC患者和健康对照者之间存在尿道微生物组成的差异.
- 微生物群失生症与BC病变发生,进展和治疗反应有关.
- 尿路微生物群作为BC风险和治疗结果的生物标志物的潜力.
结论:
- 标准化的方法对于建立因果关系至关重要.
- 尿路微生物组分析为个性化BC预防和治疗提供了潜力.
- 对宿主微生物相互作用的进一步调查对于推进BC护理至关重要.
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