电子烟依赖性肺炎是2+介导和潜在的性别特异性
Jeffrey G Shipman1, Rob U Onyenwoke1,2, Vijay Sivaraman1,3
1Department of Biological & Biomedical Sciences, North Carolina Central University, Durham, NC 27707, USA.
International journal of molecular sciences
|February 10, 2024
概括
吸烟会导致肺部疾病恶化,女性患上更大的炎症. 信号抑制减轻了这种肺损伤,这表明在与vaping相关的肺部疾病中性别依赖的作用.
科学领域:
- 肺部医学 肺部医学
- 毒理学 毒理学 毒理学
- 免疫学 免疫学 免疫学
背景情况:
- 电子烟与肺部疾病有关,但机制和性别差异尚不清楚.
- 信号传递在细胞对损伤和炎症的反应中起着至关重要的作用.
- 了解电子烟对肺部健康的影响对于公众健康至关重要.
研究的目的:
- 为了研究信号传递在吸烟引起的肺部疾病中的作用.
- 为了确定与vaping相关的肺部疾病是否存在基于性别的差异.
- 评估信号抑制在蒸汽肺损伤中的治疗潜力.
主要方法:
- 一个使用SCIREQ InExpose系统模拟 JUUL Menthol (3%尼古丁) 2 周的vaping 的小鼠模型.
- 作为预防性治疗,使用2-APB,一种信号抑制剂.
- 暴露于脂聚糖 (LPS) 诱导一个细菌感染模型后vaping.
- 使用流式细胞计,细胞因子检测和组织病理学分析支气管洗液 (BALF) 和肺组织.
主要成果:
- 在雄性和雌性小鼠中,在LPS挑战后, Vaping为加剧的疾病负担而启动肺部.
- 与雄性相比,雌性小鼠在vaping后表现出明显更高的中性恋和炎症性细胞因子水平.
- 用2-APB抑制信号传递有效控制了吸烟小鼠的炎症负担增加.
- 组织病理学分析支持吸烟小鼠,特别是雌性小鼠的肺损伤和炎症增加.
结论:
- 电子烟会加剧肺部疾病的严重程度,特别是在微生物挑战后,显着的性别特异性炎症反应.
- 信号失调与蒸汽诱导的肺损伤有关,具有潜在的性别依赖机制.
- 向信号通路可能提供一个治疗策略,以减轻与vaping相关的肺部疾病.
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