在α-Synucleinopathies中的Apolipoprotein E基因:叙述性审查
Ioannis Liampas1, Panagiota Kyriakoulopoulou2, Vasileios Siokas1
1Department of Neurology, University Hospital of Larissa, School of Medicine, University of Thessaly, 41100 Larissa, Greece.
International journal of molecular sciences
|February 10, 2024
概括
阿波蛋白E (APOE) 基因APOE4增加了患有勒维体痴呆症和帕金森病痴呆症的风险. APOE基因与帕金森病的关联因种族而异,没有发现与多个系统缩的联系.
科学领域:
- 神经遗传学 神经遗传学
- 神经退行性疾病 神经退行性疾病
- 分子生物学分子生物学
背景情况:
- 阿波利波蛋白E (APOE) 基因,特别是APOE4等位基因,是阿尔茨海默病 (AD) 的重要危险因素.
- 阿尔法同核蛋白病变 (aS病变) 包括帕金森病 (PD),帕金森病痴呆症 (PDD),勒维体痴呆症 (DLB) 和多系统缩 (MSA).
- 需要进一步阐明APOE等位基和as-pathes之间的关系.
研究的目的:
- 审查和综合有关APOE等位基因和as-pathie之间的相互作用的现有证据.
- 总结APOE等位基因对莱维体病理学和疾病表型的影响.
- 确定文献中的差距,并提出未来的研究方向.
主要方法:
- 在体外,动物和基于人类的研究的叙述性综述.
- 对APOE等位基因与PDD,DLB,PD和MSA相关的现有文献的分析.
- 检查APOE等位基和临床表现之间的表型关联.
主要成果:
- 携带APOE4是PDD和DLB的风险因素,而APOE2和APOE3似乎与PDD风险无关.
- 在DLB中APOE4的流行程度介于AD和PDD之间.
- APOE-PD的关联取决于种族;在APOE和MSA之间没有发现关联.
结论:
- APOE基因型显著影响特定α-synucleinopathies的风险和潜在的表型,特别是DLB和PDD.
- APOE4是DLB和PDD的风险因素,在神经退行性疾病中患病率各不相同.
- 需要进一步的研究来澄清APOE在PD和其他AS病症中的作用,考虑到种族变异和特定的表型影响.
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