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Updated: Jul 3, 2025

Assessment of Immunologically Relevant Dynamic Tertiary Structural Features of the HIV-1 V3 Loop Crown R2 Sequence by ab initio Folding
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Assessment of Immunologically Relevant Dynamic Tertiary Structural Features of the HIV-1 V3 Loop Crown R2 Sequence by ab initio Folding

Published on: September 15, 2010

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作为预测大型多蛋白结构的案例研究,对HIV-1多聚蛋白进行建模和分析

Ming Hao1, Tomozumi Imamichi1, Weizhong Chang1

  • 1Laboratory of Human Retrovirology and Immunoinformatics, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.

International journal of molecular sciences
|February 10, 2024
PubMed
概括

耐药性人类免疫缺陷病毒 (HIV) 菌株需要新的治疗方法. 我们开发了一种新的工作流程,以预测HIV-1 Pol蛋白质的完整结构,从而有助于开发新的抗病毒药物.

关键词:
艾滋病毒-1 波尔结构计算结构生物学 计算结构生物学域名组件 域名组件同源性建模的同源性建模不成熟的蛋白质结构建模模型循环建模的循环建模

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Multi-target Parallel Processing Approach for Gene-to-structure Determination of the Influenza Polymerase PB2 Subunit22:10

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相关概念视频

Protein Complex Assembly02:41

Protein Complex Assembly

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Protein Organization01:24

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence....
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Protein and Protein Structure02:15

Protein and Protein Structure

Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
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Protein Folding01:25

Protein Folding

Proteins are chains of amino acids linked together by peptide bonds. Upon synthesis, a protein folds into a three-dimensional conformation, critical to its biological function. Interactions between its constituent amino acids guide protein folding, and hence the protein structure is primarily dependent on its amino acid sequence.
Protein Structure Is Critical to Its Biological Function
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