相关实验视频
Updated: Jul 3, 2025

06:05
A BW Reporter System for Studying Receptor-Ligand Interactions
Published on: January 7, 2019
7.7K
cGLRs加入他们的表兄弟的模式识别受体家族来调节免疫恒温
1Laboratory of Tumor Immunology and Immunotherapy, Department of Surgery, Morehouse School of Medicine, Atlanta, GA 30310, USA.
International journal of molecular sciences
|February 10, 2024
概括
细胞质GMP-AMP合成酶 (cGAS) 和INterferon基因的STimulator (STING) 是新发现的模式识别受体 (PRR),可以启动免疫反应. 它们的失调与各种疾病有关,提供治疗点.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
- 分子生物学分子生物学
背景情况:
- 模式识别受体 (PRRs) 对于宿主防御至关重要,识别病原体相关的分子模式 (PAMPs/MAMPs) 和损伤相关的分子模式 (DAMPs).
- 具有良好的特征的PRR包括托尔类受体 (TLR),NOD类受体 (NLR),C型乳素受体 (CLR) 和RIG-I类受体 (RLR).
- 细胞质与DNA传感器 (cGLR) 已经成为PRR的一个关键类别.
研究的目的:
- 讨论cGLRs作为免疫调节中的关键PRRs的出现和功能.
- 检查cGAS/STING信号通路在免疫激活中的作用.
- 探索cGAS/STING调节失调在疾病和免疫平衡中的影响.
主要方法:
- 对cGLRs现有文献的审查和综合,重点关注cGAS/STING途径.
- 对cGAS识别细胞质dDNA的机制的分析.
- 检查STING依赖的下游信号通路,包括I型IFN释放和NF-κB激活.
主要成果:
- cGAS 识别了细胞质dDNA,启动了依赖于STING的免疫反应,如I型IFN释放,NF-κB激活,自和细胞衰老.
- cGAS/STING通路在先天性和适应性免疫中起着重要作用.
- 对cGAS/STING信号的失调与各种疾病有关,包括感染,自身免疫和癌症.
结论:
- cGLRs,特别是cGAS/STING通路,是调节免疫反应的重要PRRs.
- 了解cGAS/STING信号及其与其他PRR交叉交谈对于维持免疫平衡至关重要.
- 准cGAS/STING通路有望为一系列疾病开发新型疫苗和免疫疗法.
相关概念视频
Diversity of Antigen Receptors
589
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
589
T Cell Types and Functions
1.0K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.0K
Inflammatory Response
2.0K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
2.0K
T Cell Activation and Clonal Selection
733
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
733
G Protein-coupled Receptors
12.0K
G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
12.0K
Immunoglobulin-like Cell Adhesion Molecules
3.3K
Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
3.3K

