在环境的致癌性毒性耐受性
Aleksandar Cirovic1, Soisungwan Satarug2
1Institute of Anatomy, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
International journal of molecular sciences
|February 10, 2024
概括
暴露,主要是通过饮食,通过影响必需金属吸收和基因表达增加癌症风险. 身体的铁含量显著影响的吸收,特别是在预防乳腺癌方面.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 癌症研究 癌症研究
背景情况:
- (Cd) 是一种广泛存在的环境毒性物质,对公众健康有重大影响.
- 饮食和吸烟是的主要非职业暴露途径.
- 的吸收是由必不可少的金属载体介导的,由于排泄有限,会影响身体负担.
研究的目的:
- 审查连接慢性暴露与瘤疾病的流行病学证据.
- 强调体内铁储存在吸收和乳腺癌风险中的作用.
- 讨论在细胞转化和细胞毒性抵抗中的机制.
主要方法:
- 对暴露和癌症风险的流行病学研究的审查.
- 分析生物试验数据,证明诱导的瘤.
- 在体外研究对细胞转化和耐受性的影响.
主要成果:
- 流行病学数据将慢性暴露与肺癌以外的各种癌症风险增加联系起来.
- 暴露于会在小鼠的多种组织中诱导瘤.
- 在实验室中,长时间暴露于会使非瘤原生的人体细胞转化为恶性细胞.
结论:
- 慢性环境暴露与瘤疾病风险增加有关.
- 身体的铁状况是影响吸收和潜在的乳腺癌风险的关键因素.
- 影响基因表达和细胞过程,有助于癌症的发展和抗毒性.
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