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罗萨文通过调节TLR-4/NF-κB/MAPK信号通路来缓解LPS引起的急性肺损伤

Qiao-Hui Liu¹, Ke Zhang¹, Shu-Shu Feng¹

¹Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education, College of Pharmacy, Shihezi University, Shihezi 832002, China.

International journal of molecular sciences

|February 10, 2024

概括

罗莎,源自Rhodiola rosea L.,通过抑制关键炎症途径,显示出对急性肺损伤 (ALI) 的保护作用. 这种天然化合物在治疗ALI方面表现有前途,这种疾病的死亡率很高.

科学领域:

药理学药理学是指药理学的学科.
免疫学免疫学免疫学
细胞生物学细胞生物学

背景情况:

急性肺损伤 (ALI) 是一种严重的炎症状况,具有显著的发病率和死亡率.
罗萨文是一种来自Rhodiola rosea L.的类葡萄糖,具有已知的抗炎和抗氧化特性.
罗萨在ALI中的精确分子机制和治疗潜力在很大程度上仍未被探索.

研究的目的:

为了研究罗莎在体外对脂聚糖 (LPS) 刺激细胞的抗炎作用.
在小鼠模型中评估罗莎对LPS诱导的ALI的保护效果.
阐明罗萨在ALI中的治疗作用的基础分子机制.

主要方法:

在体外研究中使用了用LPS刺激的RAW264.7和A549细胞系.
通过LPS注射建立了ALI的体内小鼠模型.
转录组学分析和西方斑点测试被用来检查分子通路.

主要成果:

罗萨文抑制了RAW264.7细胞中的托尔样受体4/核因子-卡帕B (TLR-4/NF-κB) 信号通路.
罗萨文减少了由LPS刺激的A549细胞释放的炎症因素.
在体内,罗莎剂量取决于改善肺部组织病理学,减少炎症标志物,并抑制TLR-4/NF-κB/MAPK信号传递和亡.

结论:

罗萨文具有显著的抗炎和抗肺损伤作用.
罗莎在ALI中的治疗效益是通过抑制TLR-4/NF-κB/MAPK信号通路进行介导的.
罗萨文代表了治疗急性肺损伤的潜在治疗候选者.

关键词:

在TLR-4/NF-κB/MAPK路径中.肺部急性肺损伤是什么这是一种抗炎药物.网络药理学网络药理学罗莎维恩 (Rosavin) 罗莎维恩 (Rosavin) 是一个著名的作家.转录基因组测序的转录基因组测序

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