人类乙氨基基细胞中的TRPV1通道:功能表达和炎症调节
Tobias Weihrauch1, Natalie Gray1,2, Daniela Wiebe1
1Division of Experimental Allergy and Immunodermatology, Faculty of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, 26129 Oldenburg, Germany.
International journal of molecular sciences
|February 10, 2024
概括
人类乙酸细胞表达功能TRPV1通道,影响免疫细胞功能和存活. 这些通道在诸如阿托皮性皮炎之类的炎症状况中被上调,这表明它们在神经免疫相互作用中起作用.
科学领域:
- 免疫学 免疫学 免疫学
- 神经科学是一个神经科学.
- 细胞生物学 细胞生物学
背景情况:
- 暂时受体潜在化物1 (TRPV1) 是一种在感觉神经元和免疫细胞上发现的离子通道.
- 它在人类乙氨基基基功能和炎症调节中的作用尚不清楚.
研究的目的:
- 为了研究TRPV1在人类乙氨基细胞中的表达和功能.
- 确定TRPV1是否受到炎症状况的调节,特别是亚托皮性皮肤炎 (AD).
主要方法:
- 使用定量PCR (qPCR),流细胞测量和免疫组织化学来检查TRPV1的表达.
- 流量,亡,细胞因子调节,酸性pH效应和CD69外部化通过流动细胞计量来评估TRPV1的功能.
主要成果:
- TRPV1的激活导致了的流入和延长了乙氨基细胞的存活时间.
- 虽然TRPV1激动剂没有直接激活乙素,但主要在TRPV1阳性乙素中观察到IL-3或GM-CSF激活.
- 细胞外酸化和炎症性细胞因子 (IL-3,IL-31,IL-33,TSLP,TNF-α,BDNF,NGF-β) 增加了TRPV1的表面表达.
- 在阿托皮性皮肤炎的皮肤中,在外周神经附近发现了TRPV1表达的乙氨基基基.
结论:
- 人类乙酸细胞表达功能TRPV1通道.
- 酸性pH和AD相关的细胞因子增强了TRPV1的表达.
- 在AD皮肤中,eosinophils上TRPV1的存在表明它在炎症性皮肤疾病中的神经免疫通信中起着作用.
相关概念视频
T Cell Types and Functions
1.0K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.0K
Mechanically-gated Ion Channels
6.4K
Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
6.4K
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal
2.2K
Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
2.2K
Inflammatory Response
2.0K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
2.0K
Asthma: Pathogenesis and Management
398
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
398


