粘液结构,粘弹性质和慢性呼吸道疾病中的组成
Michela Abrami1, Alice Biasin1, Fabiana Tescione2
1Department of Engineering and Architecture, University of Trieste, Via Valerio 6/A, I-34127 Trieste, Italy.
International journal of molecular sciences
|February 10, 2024
概括
在慢性呼吸道疾病 (如喘,COPD和囊性纤维化) 中,呼吸道粘液变得异常,损害呼吸道防御. 唾液生物标志物可能有助于追踪疾病严重程度和治疗反应.
科学领域:
- 肺部医学 肺部医学
- 生物材料科学 生物材料科学
- 粘膜免疫学 粘膜免疫学
背景情况:
- 呼吸道粘液是关键的防御凝,对粘膜清除至关重要.
- 在喘,COPD和囊性纤维化 (CF) 等慢性呼吸道疾病 (CRD) 中,粘液的过度生产和变化的特性会损害呼吸道防御.
- 这导致对微生物感染和呼吸道损伤的易感性增加,造成阻塞和感染的循环.
研究的目的:
- 审查CRD中正常和病态呼吸道粘液 (唾液) 的特征.
- 探索唾液生物标志物的潜力,以监测疾病恶化和治疗疗效.
主要方法:
- 关于正常和病态状态下粘液组成,结构和风病学的文献综述.
- 唾液生物标志物的分析,包括粘膜,炎症蛋白,和代谢物.
- 讨论影响粘液性质的当前和新兴治疗策略.
主要成果:
- 在CRD中的病理性粘液表现出改变的粘素含量,结构 (网状网状大小),质,pH和透压.
- 唾液生物标志物显示出表明急性恶化和对治疗的反应的前景.
- 有证据表明,治疗可以修改的特性,但需要进一步的研究.
结论:
- 了解CRDs的粘液病理生理学对于开发有效的治疗方法至关重要.
- 唾液生物标志物为个性化医疗提供了一个潜在的途径,用于管理CRDs.
- 需要进一步的研究来验证唾液生物标志物作为疾病严重程度和治疗结果的可靠相关值.
相关概念视频
Drugs Used in Upper Respiratory Disorders: Overview
248
Upper respiratory tract disorders, including viral infections and allergic rhinitis, cause significant discomfort and disrupt daily life. Managing these conditions involves a variety of drugs, such as antihistamines, intranasal steroids, decongestants, antitussives, expectorants, and mucolytics. Specific examples of drugs in each category are provided.
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
248
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
2.8K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
2.8K
The Bronchial Tree
2.6K
The human bronchi and bronchial tree play a crucial role in the respiratory system, facilitating the exchange of oxygen and carbon dioxide. Let's delve into the intricate structure and functions of these respiratory components.
The trachea, commonly known as the windpipe, is a tube that connects the larynx (voice box) to the bronchi. At a point called the carina, it bifurcates into two primary bronchi. The right primary bronchus is wider, shorter, and more vertical than the left primary...
The trachea, commonly known as the windpipe, is a tube that connects the larynx (voice box) to the bronchi. At a point called the carina, it bifurcates into two primary bronchi. The right primary bronchus is wider, shorter, and more vertical than the left primary...
2.6K
Factors Affecting Pulmonary Ventilation
1.4K
Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
1.4K
Asthma: Pathogenesis and Management
398
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
398
Chronic Obstructive Pulmonary Disease-V: Management
2.5K
Managing Chronic Obstructive Pulmonary Disease (COPD) involves a multifaceted approach to reduce symptoms, prevent exacerbations, improve overall health status, and slow disease progression. Key strategies include lifestyle modifications, pharmacotherapy, supportive therapies, and, in some cases, surgery. Here is an overview of the primary COPD management strategies:
Smoking Cessation
Smoking Cessation
2.5K


