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红肉消费与晚期结肠直肠腺瘤之间的关联在加拿大阿尔伯塔省接受查相关结肠镜检查的人群中
Eliya Farah1,2, John M Hutchinson1,2, Yibing Ruan2,3
1Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.
Cancers
|February 10, 2024
概括
加工和总体红肉摄入量,但不包括未加工的红肉,与晚期结直肠腺瘤 (ACRAs) 的几率增加有关. 区分肉类对于了解癌前结直肠病变的饮食风险至关重要.
科学领域:
- 胃肠病学 胃肠病学
- 营养流行病学 营养流行病学
- 在瘤学瘤学.
背景情况:
- 结肠直肠癌风险与红肉有关,但其在早期癌前病变 (如晚期结肠直肠腺瘤 (ACRAs)) 中的作用需要澄清.
- 了解特定的红肉类对ACRA发展的影响对于有针对性的饮食建议至关重要.
研究的目的:
- 调查不同类型的红肉消费 (总体,加工,未加工) 与ACRAs存在之间的关联.
- 为了确定未经加工的红肉摄入量与加工或全部红肉相比,其与ACRAs的关联是否不同.
主要方法:
- 一项涉及1083名年龄在50岁以上,在阿尔伯塔省卡尔加里接受查结肠镜检查的人的横截面研究.
- 通过使用饮食史问卷来评估总体,加工和未加工红肉的饮食摄入量.
- 用多变量后勤回归和立方线模型来评估肉类摄入量和ACRA之间的关联.
主要成果:
- 在未经加工的红肉摄入量和ACRAs之间没有发现显著的关联.
- 增加红肉总摄入量 (10g/d) 与更高的ACRAs几率相关 (aOR=1.05).
- 增加加工肉类的摄入量 (10g/d) 与更高的ACRAs几率 (aOR=1.11) 有关.
结论:
- 加工和全部红肉消费,不包括未经加工的红肉,与晚期结直肠腺瘤的风险增加有关.
- 区分红肉类型对于评估与ACRAs相关的饮食风险很重要.
- 调查结果强调,需要针对加工肉类摄入量制定具体的饮食指南,以减轻ACRA风险.
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