对乳腺癌的性别特异性遗传倾向:BRCA基因及其他基因
Virginia Valentini1, Agostino Bucalo1, Giulia Conti1
1Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy.
Cancers
|February 10, 2024
概括
乳腺癌 (BC) 影响女性和男性,遗传因素影响风险. 了解男性乳腺癌的遗传差异是改善个性化护理和在BC治疗中实现性别平等的关键.
科学领域:
- 在瘤学瘤学.
- 遗传学 遗传学 是一个
- 性别研究是性别研究.
背景情况:
- 乳腺癌 (BC) 常常被误认为只影响女性,但它也发生在男性和跨性别者身上.
- 遗传倾向显著影响BC风险,影响所有受影响性别的精确预防和治疗策略.
- 了解性别特异性遗传因素对于公平的BC护理至关重要.
研究的目的:
- 审查关于遗传倾向导致乳腺癌 (BC) 的最新研究.
- 突出男性和女性BC.的遗传基础上的相似性和差异.
- 讨论对以性别为导向的临床管理的影响,并实现医疗保健平等.
主要方法:
- 关于乳腺癌遗传风险因素的当前科学文献的综述.
- 分析下一代测序和全基因组关联研究的发现.
- 综合研究的高,中和低透风险变体在BC易感性.
主要成果:
- 结核病易感性的遗传结构在两性之间在很大程度上是相似的,涉及高,中和低透率的变体.
- 在BRCA1和BRCA2中,高透性致病变体 (PVs) 是关键的风险因素,BRCA1 PVs与女性BC和BRCA2 PVs与男性BC更相关.
- 新出现的证据表明,与女性BC相比,男性BC的基因基础是不同的,这会影响风险评估和治疗.
结论:
- 遗传因素在所有性别的乳腺癌 (BC) 倾向中发挥着关键作用.
- 承认男性乳腺癌是基于其遗传成分的独特实体,对于个性化风险评估和治疗至关重要.
- 建立以性别为导向的临床管理对于实现BC护理中的平等至关重要.
关键词:
这是一个ATMATMATM.这就是BRCA BRCA.CHEK2 是一个国家.在PALB2中,PALB2是PALB2.在PRS中使用PRS.乳腺癌 乳腺癌 乳腺癌性别瘤学 性别瘤学男性的乳腺癌是男性的乳腺癌.个性化的临床管理.风险评估 风险评估 风险评估更多相关视频
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