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在头部和部状细胞癌中评估新的瘤芽

Claudio Cacchi¹, Henrike J Fischer², Kai Wermker³

¹Institute of Pathology, School of Medicine, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany.

|February 10, 2024

概括

在头部和部状细胞癌 (HNSCC) 中,瘤芽 (TB) 的评估需要仔细考虑组织固定. 随机选择的边缘可能无法可靠地预测结果,突出了对标准化方法的需求.

科学领域:

在瘤学瘤学.
病理学病理学病理学
历史形态学历史形态学

背景情况:

瘤芽 (TB) 是入侵前线的一个关键组织形态学特征.
结核病影响头支状细胞癌 (HNSCC) 的预后结果预测.

研究的目的:

分析FFPE固定与冷固定HNSCC组织中的结核病评分的可靠性.
评估结核病得分与瘤攻击性和患者结果的相关性.

主要方法:

从66名HNSCC患者的FFPE固定瘤切片中分析平均结核病得分 (TB rel).
在FFPE和冷固定截面之间比较结核病得分.
结核病得分与淋巴结转移,额外囊生长和分级的相关性.

主要成果:

结核病rel与瘤攻击性标志物有显著的相关性.
结核病得分在同一患者的FFPE部分内具有不同边际的变化.
固定方法影响结核病评分的确定,与FFPE相比,冷截面显示不准确.

结论:

随机选择的边缘切割是不可靠的预测预后结果,由于结核病得分的变化.
结核病rel提供了一种潜在的方法来标准化结核病评分分析,并弥补观察者间/方法间的差异性.
与冷固定相比,FFPE固定在HNSCC中更可靠地准确确定结核病得分.

关键词:

在HNSCC中,我们可以看到HNSCC.癌症癌症癌症癌症癌症口腔癌是指口腔癌的发生.瘤是一个瘤.瘤的芽是因为瘤芽.瘤标志物是一种瘤标志物.

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