预后因素和冠状腺瘤的诺莫图:基于人口的回顾性监测,流行病学和最终结果数据库分析
Abhishek S Bhutada1, Srijan Adhikari1,2,3, Joshua A Cuoco1,2,3
1Virginia Tech Carilion School of Medicine, 2 Riverside Circle, Roanoke, VA 24016, USA.
Cancers
|February 10, 2024
概括
对于罕见的中枢神经系统冠状动脉瘤 (CPTs) 的最佳治疗方法因类型而异. 总体切除 (GTR) 或亚总切除 (STR) 对乳头瘤和非典型乳头瘤的存活率相似,而CPC受益于辅助治疗的GTR或STR.
科学领域:
- 神经瘤学神经瘤学
- 手术瘤学手术瘤学
- 流行病学 流行病学
背景情况:
- 胸膜瘤 (CPT) 是一种罕见的中枢神经系统瘤,占所有脑瘤的1%.
- 冠状动脉瘤包括冠状动脉瘤 (CPP),非典型冠状动脉瘤 (aCPP) 和冠状动脉癌 (CPC).
- 有限的前性数据存在于aCPP和CPC的新辅助疗法,尽管总体切除 (GTR) 为CPP提供了长期生存.
研究的目的:
- 分析基于组织学和治疗的CPT患者的生存结果.
- 确定影响CPT患者整体存活时间 (OS) 的预后因素.
- 开发一个预测CPC存活的诺米图.
主要方法:
- 从SEER数据库中对679名CPT患者 (2000-2019年) 的回顾性分析.
- 组织学亚型包括CPP (n=456),aCPP (n=75) 和CPC (n=142).
- 考克斯的比例危险模型评估了OS预测因素;为CPC生存预测构建了一个名图.
主要成果:
- 五年后的OS率为CPP的90%,aCPP的79%,CPC的61%.
- 对于CPP或aCPP,GTR和STR没有显著的OS差异.
- 对于CPC,GTR比单独的STR改善了OS,但OS与辅助疗法之间的GTR和STR相当. 诺莫图显示了可以接受的准确性 (C指数=0.608).
结论:
- 这项研究提供了对罕见CPT的最佳治疗策略的见解.
- 对于CPP和aCPP,手术切除程度 (GTR与STR) 不会影响OS.
- 对于CPC,GTR或STR与辅助疗法产生相当的OS,建议量身定制的治疗方法.
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