样本 entropy 改善在早期多发性硬化症的姿势控制的评估
L Eduardo Cofré Lizama1, Xiangyu He1, Tomas Kalincik2,3
1Department of Medicine, The University of Melbourne, Melbourne, VIC 3052, Australia.
Sensors (Basel, Switzerland)
|February 10, 2024
概括
样本 (SE) 有效地识别了多发性硬化症 (pwMS) 患者的早期姿势障碍,优于传统措施. 在特定条件下,SE分析,特别是在前后后方向,显示出追踪疾病进展的前途.
科学领域:
- 神经学 神经学
- 生物医学工程 生物医学工程
- 康复科学 康复科学 康复科学
背景情况:
- 姿势障碍是多发性硬化症 (MS) 进展的早期指标.
- 目前的疾病评估工具对早期多发性硬化症缺乏敏感性.
- 样本 (SE) 显示了检测微妙功能缺陷的潜力.
研究的目的:
- 将SE的敏感性和特异性与线性测量进行比较,以区分患有MS的人 (pwMS) 和健康对照人 (HC).
- 评估SE检测早期多发性硬化和轻度多发性硬化 (EDSS ≤2.0) 的能力.
主要方法:
- 58名pwMS (EDSS ≤4) 和23名HC在硬面或泡面上静静地站立,眼睛打开或闭上.
- 摇摆记录在胸骨和腰椎.
- 计算了线性测量和SE (前后和中侧);多变量ANOVA和AUC-ROC用于分析.
主要成果:
- 与HC相比,pwMS在大多数条件下表现出明显较低的SE.
- 在前后方向闭上眼睛的硬表面上,SE表现出最强的分辨能力 (AUC = 0.747),即使对于轻度的MS.
- 观察到取决于任务的差异,SE (前后,硬表面,闭眼) 是 pwMS 的最佳分类器.
结论:
- 在pwMS中,SE是检测早期姿势障碍的敏感措施.
- SE提供了一种有价值的工具,用于监测多发性硬化症的进展,并评估干预的有效性.
- 在特定具有挑战性的条件下,前后SE显示出早期MS检测的高潜力.
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