与COVID-19肺炎相关的肺血栓症:超越了经典的肺血栓栓塞
Carla Suárez-Castillejo1,2, Néstor Calvo3, Luminita Preda3
1Servicio de Neumología, Hospital Universitario Son Espases, Palma de Mallorca, Spain.
European journal of clinical investigation
|February 10, 2024
概括
在COVID-19肺炎中,局部肺血栓症 (PT) 比经典的肺血栓栓塞 (TE) 更多. 在肺不透明中发现了瘤,支持PT作为COVID-19患者的主要机制.
科学领域:
- 肺血管疾病是肺血管疾病.
- 传染病病理学 传染病病理学
- 放射学和成像学 放射学和成像学
背景情况:
- 肺栓塞 (PT) 和血栓栓塞 (TE) 是COVID-19中争论的机制.
- 以前的研究是回顾性的,缺乏强有力的证据.
- 患者的选择倾向于怀疑TE.
研究的目的:
- 为了前性地研究COVID-19肺炎中血栓形成的机制.
- 要区分本地PT和经典TE.
- 为了将血栓位置与肺部不透明度相关联.
主要方法:
- 对接受CT肺血管造影的COVID-19肺炎患者进行前性研究.
- 使用人工智能,被肺化 (TSO) 和肺部全参与 (TLI) 包围的量化血栓.
- 分析了患者和个体凝块水平上的血栓分布.
主要成果:
- 在70/184名患者中诊断出TE;检测到3个/患者的血栓.
- 每名患者的TSO比例为100%,而TLI为19.9%.
- 92.9%的患者显示TSO超过TLI,表明非随机的血栓分布.
结论:
- 这些发现支持COVID-19中的本地PT超过经典TE.
- 血栓始终位于肺不透明处,无论TLI或凝块位置如何.
- 这表明COVID-19相关的血栓形成起源于肺内局部.
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