皮层时间尺度和结构和功能大脑网络的模块化组织
Daniel J Lurie1,2, Ioannis Pappas3, Mark D'Esposito4
1Department of Psychology, University of California, Berkeley, California, USA.
Human brain mapping
|February 10, 2024
概括
区域大脑活动时间尺度与网络组织相关. 较长的时间尺度与更强大的社区内部功能连接和多样化的结构连接有关,揭示了大脑结构-功能关系的洞察力.
科学领域:
- 神经科学是一个神经科学.
- 认知神经科学 认知神经科学
- 系统神经科学 系统神经科学
背景情况:
- 对区域大脑动态及其与大脑结构和功能的联系越来越感兴趣.
- 在休息期间脑活动波动的时间尺度上观察到区域差异.
- 皮层时间尺度,局部电路和区域间连接之间的以前的关联.
研究的目的:
- 研究血氧水平依赖 (BOLD) 功能磁共振成像 (fMRI) 时间表与结构和功能大脑网络的模块化组织之间的关系.
- 在多个尺度上描述网络社区结构.
- 探索时间尺度如何与社区内连接以及宏观大脑网络中的拓作用有关.
主要方法:
- 分析BOLD fMRI数据,以获得区域时间表.
- 在结构和功能大脑网络中模块化社区结构的表征.
- 统计分析以评估时间尺度和网络属性之间的相关性.
主要成果:
- 较长的时间尺度与更大的社区内部功能连接有关.
- 较长的时间尺度与多样化的结构连接性相关.
- 时间尺度和结构连接度之间的正相关性被复制.
- 发现并复制了具有相似时间尺度的皮质区域之间优先功能连接的证据.
结论:
- 皮层动态的区域差异与宏观大脑网络中的拓作用有关.
- 研究结果支持这样一个观点:大脑网络的组织会影响区域大脑活动的时间表.
- 这项研究增强了对人类大脑结构功能关系的理解.
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