一种基于酸盐/酸盐的优化微封装石灰皮精油及其作为抗菌织品的应用
Nastiti Nur Indriyani1, Jamaludin Al-Anshori1, Tatang Wahyudi2
1Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor, Indonesia.
Journal of biomaterials science. Polymer edition
|February 10, 2024
概括
使用皮精油 (LPEO) 封装在酸盐/酸盐微囊中开发了功能性织品. 这些不动化的微囊显示出对各种细菌有前途的抗菌活性,为抗微生物织应用提供了潜力.
科学领域:
- 材料科学 材料科学 材料科学
- 生物技术是生物技术.
- 织工程 织工程 织工程
背景情况:
- 精油,如皮精油 (LPEO) 来自*C. aurantifolia*,具有固有的抗菌特性.
- 开发具有抗微生物能力的功能性织品对于医疗保健和卫生应用至关重要.
- 微封装技术对于保护和控制诸如精油等活性化合物的释放至关重要.
研究的目的:
- 用LPEO微囊固定功能性织品的准备和特征.
- 为了优化LPEO的微封装过程,使用奇托/酸和三聚酸.
- 评估固定式LPEO微囊的抗菌疗效和释放动力学.
主要方法:
- 顺序优化酸盐/酸盐比率,LPEO质量和三聚酸 (STPP) 度用于同化.
- 微囊的特性,包括产量,油含量 (OC),封装效率 (EE),颗粒大小和形态.
- 抗菌检测针对格拉姆阳性 (*S. aureus*, *S. epidermidis*) 和格拉姆阴性 (*E. coli*, *K. 肺炎*) 的细菌.
- 使用Avrami的模型分析LPEO释放动力学,并评估热稳定性和长期OC保留.
主要成果:
- 优化条件 (0.2g LPEO, 5:3 CH/AG比, 2% STTP) 产生了53.45%的产量,65.08%的OC和85.04%的EE.
- 微囊呈现球形 (0.757毫米平均尺寸) 并遵循零顺序释放动力学.
- 固定化的微囊显示出良好的热稳定性 (高达122°C),并在四周后保持38%的OC.
- 在布上成功固定 (70.34%) 导致对*S. aureus*的强烈抑制和对其他测试细菌的中等活性.
结论:
- 建立了一个强大的方法来制备LPEO固定功能织品.
- 开发的微囊提供可控释放,良好的稳定性和显著的抗菌特性.
- 这项技术有可能为各种应用创造先进的抗微生物织品.
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