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Updated: Jul 3, 2025

Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes
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染色体DNA上的G-四重复体会负面调节拓酶1的活性

Hui-Ting Liang1,2, Jiang-Yu Yan1, Hao-Jun Yao1

  • 1School of Biomedical Sciences, Hunan University, Changsha 410082, China.

Nucleic acids research
|February 10, 2024
PubMed
概括

人类DNA拓酶1 (Top1) 被G-四重复 (G4) DNA结构困住,阻碍了它的功能. 破坏这种与G4配体的相互作用会激活Top1并增加癌细胞对抑制剂的敏感性.

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