伴随性疾病的负担:非小细胞肺癌期间的骨质疏松性脊椎骨折 - - BONE研究
概括
骨质疏松性脊椎骨折 (OPVF) 在非小细胞肺癌 (NSCLC) 患者中很常见,风险因素包括低BMI,低骨密度和皮质类固醇使用. 在NSCLC患者中,建议对骨质疏松症进行查.
科学领域:
- 在瘤学瘤学.
- 骨的新陈代谢 骨的新陈代谢
- 放射学 放射学是一门学科.
背景情况:
- 免疫疗法和向治疗改善了非小细胞肺癌 (NSCLC) 的存活率,导致骨质疏松症等并发症的增加.
- 骨质疏松性脊椎骨折 (OPVF) 在这个不断增长的患者群体中是一个重大问题.
研究的目的:
- 在随访期间评估OPVF在NSCLC患者的流行率和发病率.
- 识别与OPVF发展相关的风险因素.
- 确定OPVF对整体存活时间 (OS) 的影响.
主要方法:
- 长度,单中心,对NSCLC患者的回顾性队列研究.
- 胸部-腹部-骨盆计算断层扫描 (CAP CT) 扫描对OPVF,骨密度和时间进行了审查.
- 用于风险因素分析和OS计算的二进制物流回归和卡普兰-梅尔方法.
主要成果:
- OPVF患病率从纳入时的10.7%增加到随访时的23.2%.
- OPVF的累积发病率为12.5%,发病率为每100个患者年中的4个.
- OPVF的独立风险因素包括BMI<19 kg/m2,较低的骨密度 (TVBD) 和皮质类固醇使用. OPVF没有显著影响OS.
结论:
- 骨质疏松症查对于非小细胞肺癌患者至关重要.
- 胸部瘤学家应该加强对管理类固醇诱导骨质疏松症的建议的应用.
关键词:
身体质量指数 (BMI) 是一个指标.图像扫描 (CT) 扫描是一种扫描.皮质类固醇是一种皮质类固醇.非小细胞肺癌是非小细胞肺癌.骨质疏松症是一种骨质疏松症.骨质疏松性脊椎骨折 骨质疏松性脊椎骨折椎间板体体积骨密度 椎间板体体积骨密度脊椎骨折是指脊椎骨折的发生.更多相关视频
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