根据COVID-19住院患者的临床结果严重程度评估药物使用模式:一项回顾性药物使用研究
Renato Ferreira-da-Silva1, Priscila Maranhão2, Cláudia Camila Dias3
1Porto Pharmacovigilance Centre, Faculty of Medicine of the University of Porto, Porto, Portugal; CINTESIS@RISE, Department of Community Medicine, Information and Health Decision Sciences (MEDCIDS), Faculty of Medicine of the University of Porto (FMUP), Porto, Portugal.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
|February 10, 2024
概括
COVID-19患者的药物治疗模式与疾病的严重程度和结果有显著的相关性. 特定的药物类别,包括形成血液的药物和神经系统药物,与重症监护室的入院和死亡率有关.
科学领域:
- 药理学 药理学是指药理学的学科.
- 传染性疾病 传染性疾病
- 临床医学 临床医学
背景情况:
- COVID-19 构成了全球重大健康挑战,需要对影响患者结果的因素有深入的了解.
- 严重的COVID-19病例的有效管理依赖于优化治疗干预措施和监测治疗反应.
研究的目的:
- 分析葡萄牙住院COVID-19患者的药物使用模式.
- 调查特定药物治疗方案与临床结果之间的关联,包括疾病严重程度和死亡率.
主要方法:
- 来自电子健康记录的住院药物数据的回顾性分析.
- 用于药物编码的使用解剖治疗化学物质 (ATC) 分类.
- 采用多变量分析来调整人口统计和并发症,评估ICU入院和死亡率等结果.
主要成果:
- 在2688名患者中确定了药物类型/强度和COVID-19严重程度之间的显著相关性.
- 血液和造血器官药物与ICU入院和ECMO支持有关.
- 在非幸存者中,神经系统和生殖泌尿激素更为普遍;在危急情况下,使用皮质类固醇和托西利祖马布.
- 广泛使用的药物 (食道,新陈代谢,心血管) 与更严重的病例有关;与机械通风相关的抗感染药物和肌肉骨药物.
结论:
- 复杂的药物治疗方案是管理严重COVID-19的重要组成部分.
- 特定的药物处方模式与关键的临床结果和疾病进展有关.
- 需要进一步的研究来阐明COVID-19中这些复杂的药物治疗关系.
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