在患有新生儿腹的小牛中,对周围循环淋巴细胞和血清水平的免疫类型鉴定
Murat Uztimür1, Ömer Kizil2, Hatice Handan Akbulut3
1Bingöl University Faculty of Veterinary Medicine, Department of Internal Medicine, Selahaddin-i Eyyubi, Bingöl, Turkey.
Veterinary immunology and immunopathology
|February 10, 2024
概括
新生儿腹在小牛中改变了免疫反应,特定的传染物影响CD4+和CD8+T淋巴细胞水平. 缺乏可能是受影响小牛的因素.
科学领域:
- 兽医免疫学 兽医免疫学
- 动物卫生 动物健康
- 新生儿小牛疾病 新生儿小牛疾病
背景情况:
- 新生儿腹是小牛患病和死亡的重要原因.
- 了解对各种病原体的免疫反应对于有效管理至关重要.
- 微量元素如在新生儿小牛免疫力中的作用需要进一步研究.
研究的目的:
- 为了阐明CD4+和CD8+T淋巴细胞对新生儿腹的小牛感染传染剂的免疫反应.
- 确定这些小牛的血清水平和T淋巴细胞亚型之间的关联.
主要方法:
- 一组50只新生小牛 (1-28天大) 根据病原体分组:罗塔病毒,Cryptosporidium parvum (C.parvum),冠状病毒,罗塔病毒+C.parvum以及对照组.
- 使用ICP-MS.分析了血清水平.
- 使用流细胞计量来量化CD4+和CD8+T淋巴细胞水平.
主要成果:
- 虽然两组之间没有发现血清的显著差异,但对照组的血清水平不足.
- 罗塔病毒+C.parvum组的CD4+T淋巴细胞水平明显高于冠状病毒组.
- 与对照组,罗塔病毒,C.parvum和罗塔病毒+C.parvum组相比,冠状病毒组的CD8+T淋巴细胞水平显著增加.
- 在水平和CD4+ T淋巴细胞之间观察到显著的负相关性.
- 与对照组相比,罗塔病毒,C.parvum和冠状病毒组的纤维素和白细胞计数显著增加.
结论:
- 显著的CD4+和CD8+T淋巴细胞免疫反应与小牛新生儿腹的特定病因因素有关.
- 在患有新生儿腹的小牛中,缺乏是重要的考虑因素.
- 这些发现突出了感染,免疫状况和新生儿小牛健康中的营养因素之间的复杂相互作用.
关键词:
和 流动细胞计量 流动细胞计量CD4+ CD4+ CD4+ CD4+ CD4+ CD4+ CD4+ CD4+ CD4+ CD4+ CD4+ CD4+CD8 + CD8 + CD8 + CD8 + CD8 + CD8 + CD8 + CD8 + CD8小牛腹 小牛腹是一种.更多相关视频
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